A LABILE IRON POOL

Existence of an Erythropoitic labile iron pool

existence of an erythropoitic labile iron pool

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The role of labile iron pool in cardiovascular diseases.

Although multiple factors are associated with cardiovascular pathology, there is now an impressive body of evidence that free radicals and nonradical oxidants might cause a number of cardiovascular dysfunctions. Both direct damage to cellular components and/or oxidation of extracellular biomolecules, e.g. LDL, might be involved in the aetiology of cardiovascular diseases. The key molecules in t...

Leukocyte labile iron pool in patients with systolic heart failure.

INTRODUCTION Data regarding sources of oxidative stress in the failing myocardium are sparse. Leukocytes actively participate in the oxidative damage observed in human heart failure (HF). The intracellular labile iron pool (LIP) represents a source of toxic reactive oxygen species. METHODS We studied patients with chronic systolic HF who had a left ventricular ejection fraction (LVEF) 45%. We...

Fluorescence measurements of the labile iron pool of sickle erythrocytes.

Sickle erythrocytes have increased ferritin and increased molecular iron on the inner membrane leaflet, and we postulated that cytosolic labile iron is also elevated. We used the fluorescent metallosensor, calcein, and a permeant Fe2+ chelator to estimate labile cytoslic Fe2+, and calcein plus an Fe3+ chelator to estimate total cytosolic labile iron (Fe2+ + Fe3+). We measured membrane nonheme i...